Clinical outcomes of cancer patients with pre-existing autoimmune thyroid disease treated with PD-(L)-1 inhibitors: a propensity score methodology with inverse probability of treatment weighting retrospective study - Takeaways - MDSpire

Clinical outcomes of cancer patients with pre-existing autoimmune thyroid disease treated with PD-(L)-1 inhibitors: a propensity score methodology with inverse probability of treatment weighting retrospective study

  • By

  • Yun Shi

  • Qiuyi Wang

  • Ziqing Ye

  • Doudou Chen

  • Tao Yang

  • Yongyue Wei

  • Xuqin Zheng

  • June 11, 2026

  • 0 min

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  • 1

    Preexisting thyroid antibodies significantly increase the risk of thyroid immune-related adverse events in cancer patients treated with PD-(L)1 inhibitors.

  • 2

    Patients with thyroid antibodies had a higher incidence of grade≥2 irAEs, confirming the association between thyroid autoimmunity and adverse events.

  • 3

    No significant difference in overall survival was found between patients with and without thyroid antibodies in this study.

  • 4

    Patients with thyroid antibodies who developed irAEs exhibited better survival outcomes, suggesting a potential link between immune activation and clinical benefits.

  • 5

    The study utilized robust statistical methods to clarify the impact of thyroid autoimmunity on safety and efficacy in patients receiving immune checkpoint inhibitors.

Original Source(s)

Clinical outcomes of cancer patients with pre-existing autoimmune thyroid disease treated with PD-(L)-1 inhibitors: a propensity score methodology with inverse probability of treatment weighting retrospective study

  • by Yun Shi, Qiuyi Wang, Ziqing Ye, Doudou Chen, Tao Yang, Yongyue Wei, Xuqin Zheng

  • June 11, 2026

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