-
1
NF-κB is a crucial integrative signaling node in osteoarthritis, linking mechanical stress, innate immune responses, and metabolic inflammation.
-
2
Context-dependent NF-κB signaling influences cartilage matrix remodeling, chondrocyte stress responses, and changes in the immune microenvironment in OA.
-
3
Osteoarthritis is characterized by chronic low-grade inflammation and maladaptive tissue remodeling, rather than solely mechanical wear and tear.
-
4
Sustained NF-κB activation disrupts the anabolic–catabolic balance in chondrocytes, leading to ECM breakdown and cellular senescence.
-
5
Emerging therapeutic strategies targeting NF-κB networks may advance precision treatment in osteoarthritis through mechanism-based patient stratification.
