Effects of a clinical metagenomics intervention on clinical outcomes, healthcare costs, and health-related quality of life in patients with sepsis or septic shock: results of the randomized-controlled DigiSep trial - Takeaways - MDSpire

Effects of a clinical metagenomics intervention on clinical outcomes, healthcare costs, and health-related quality of life in patients with sepsis or septic shock: results of the randomized-controlled DigiSep trial

  • By

  • Thorsten Brenner

  • Annabell Skarabis

  • Stefan J. Schaller

  • Thilo von Groote

  • Christian Putensen

  • Ulf Günther

  • Martin Sauer

  • Sebastian O. Decker

  • Fabian Dusse

  • Manfred Weiss

  • Klaudiusz Suchodolski

  • Tim-Philipp Simon

  • Peter Rosenberger

  • Onnen Moerer

  • Matthias Unterberg

  • Jens-Christian Schewe

  • Hendrik Bracht

  • Selina Hutzl

  • Manuel Feißt

  • Ursula Marschall

  • Patrick Brandenburg

  • Philip Stevens

  • Juliana Schmidt

  • Mathias W. Pletz

  • Marc M. Berger

  • June 30, 2026

  • 0 min

Share

  • 1

    The DigiSep trial evaluated the impact of metagenomic next-generation sequencing (mNGS) on patients with sepsis or septic shock.

  • 2

    The primary endpoint, the DOOR/RADAR score, did not show improvement in the intervention group compared to the control group.

  • 3

    Exploratory analyses indicated that mNGS might optimize anti-infective therapy and improve clinical outcomes.

  • 4

    The study included adult patients diagnosed with sepsis or septic shock within 24 hours and excluded those with imminent death.

  • 5

    Healthcare costs and health-related quality of life were assessed over 180 days to evaluate the effects of the mNGS approach.

Original Source(s)

Effects of a clinical metagenomics intervention on clinical outcomes, healthcare costs, and health-related quality of life in patients with sepsis or septic shock: results of the randomized-controlled DigiSep trial

  • by Thorsten Brenner, Annabell Skarabis, Stefan J. Schaller, Thilo von Groote, Christian Putensen, Ulf Günther, Martin Sauer, Sebastian O. Decker, Fabian Dusse, Manfred Weiss, Klaudiusz Suchodolski, Tim-Philipp Simon, Peter Rosenberger, Onnen Moerer, Matthias Unterberg, Jens-Christian Schewe, Hendrik Bracht, Selina Hutzl, Manuel Feißt, Ursula Marschall, Patrick Brandenburg, Philip Stevens, Juliana Schmidt, Mathias W. Pletz, Marc M. Berger

  • June 30, 2026

Related Content

High-Dose Vitamin C Could Pose Risk in Severe Burns

“High-dose intravenous vitamin C administered early after injury did not reduce organ dysfunction or [mortality] and should not be a treatment in severe burns.”

Gut barrier-microbiota crosstalk in sepsis: from pathogenesis to potential therapies

Neutrophil-derived ROS as a rapid functional biomarker: diagnostic and prognostic performance of the Leukocyte ImmunoTest in infection and sepsis