Cerebrospinal fluid proteomics identifies calcyphosine and follistatin-like 1 as exploratory candidate proteins of interest in hydrocephalus

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Hydrocephalus includes post-hemorrhagic hydrocephalus (PHH) and idiopathic normal pressure hydrocephalus (iNPH), which have distinct proteomic profiles.
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Cerebrospinal fluid samples from 11 participants were analyzed using Olink proximity extension assay proteomics to identify protein-abundance patterns.
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PHH showed elevated calcyphosine (CAPS) levels and reduced proteins related to neuronal maintenance, while iNPH exhibited increased follistatin-like 1 (FSTL1) levels.
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Functional annotation analyses revealed overrepresented terms related to inflammation, signaling, and neural pathways in both PHH and iNPH.
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The findings suggest that CAPS and FSTL1 may serve as exploratory proteins for further validation in hydrocephalus-related research.

Frontiers In Neurology

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