Evaluation of Treatment Response in Patients with Locally Advanced Renal Cell Carcinoma Following Previous Systemic Therapy - Takeaways - MDSpire

Evaluation of Treatment Response in Patients with Locally Advanced Renal Cell Carcinoma Following Previous Systemic Therapy

  • By

  • Konstantin E. Seifert

  • Hendrik Dinkel

  • Linda Huberth

  • Dorothee Tiedje

  • Jan Gröticke

  • Laura-Maria Krabbe

  • Frederike Tepel

  • Kambiz Rahbar

  • Christof Bernemann

  • Andres J. Schrader

  • Martin Bögemann

  • Martin Janssen

  • Katrin Schlack

  • Barbara Heitplatz

  • January 16, 2026

  • 0 min

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  • 1

    Renal cell carcinoma (RCC) cases are increasing, with approximately 400,000 new diagnoses worldwide in 2020.

  • 2

    Neoadjuvant therapy combining checkpoint inhibitors and tyrosine-kinase inhibitors shows promising tumor size reduction in RCC.

  • 3

    A retrospective analysis of 17 RCC patients evaluated the effectiveness of systemic therapy prior to surgical resection.

  • 4

    Most patients in the study had clear cell histology, with a mean primary tumor size of 9.1 cm before treatment.

  • 5

    The study aims to assess the safety and feasibility of surgical resection following preoperative systemic therapy.

Original Source(s)

Evaluation of Treatment Response in Patients with Locally Advanced Renal Cell Carcinoma Following Previous Systemic Therapy

  • by Konstantin E. Seifert, Hendrik Dinkel, Linda Huberth, Dorothee Tiedje, Jan Gröticke, Laura-Maria Krabbe, Frederike Tepel, Kambiz Rahbar, Christof Bernemann, Andres J. Schrader, Martin Bögemann, Martin Janssen, Katrin Schlack, Barbara Heitplatz

  • January 16, 2026

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