Tau Biomarker Expands Beyond Alzheimer’s
Study finds elevated phosphorylated tau in AL and ATTR amyloidosis, suggesting a potential blood biomarker for amyloid-related neuropathy
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Elevated blood levels of phosphorylated tau are found in patients with AL and ATTR amyloidosis, suggesting its potential as a diagnostic biomarker.
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The study analyzed serum samples from 280 individuals, demonstrating higher p-tau181 levels in amyloidosis patients compared to controls.
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P-tau181 showed moderate diagnostic discrimination with an area under the curve of 0.82, indicating its effectiveness in identifying amyloidosis.
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Patients with amyloidosis-related neuropathy had higher p-tau181 levels, differentiating them from individuals with neuropathy from other causes.
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The findings suggest phosphorylated tau may reflect cellular responses to amyloid deposition, warranting further research for diagnostic integration.
