Symptomatic intraocular pressure dysregulation during clopidogrel exposure after patent foramen ovale closure in a patient with ocular hypertension and angle crowding: a Case Report - Takeaways - MDSpire

Intraocular Pressure Dysregulation Symptoms Associated with Clopidogrel Treatment Following Patent Foramen Ovale Closure in a Patient with Ocular Hypertension and Angle Crowding: A Case Study

  • By

  • Faxue Li

  • Rongbo Yu

  • Xuan Guo

  • Wenyi Ji

  • Qiang Wu

  • July 16, 2026

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  • 1

    A 52-year-old woman developed ocular discomfort and blurred vision after clopidogrel treatment following patent foramen ovale closure.

  • 2

    The patient had pre-existing ocular hypertension with angle crowding but no definite glaucomatous damage prior to clopidogrel exposure.

  • 3

    Symptoms improved after clopidogrel withdrawal and recurred upon re-administration, indicating a possible association with the medication.

  • 4

    24-hour IOP monitoring during symptomatic exposure showed marked peak elevation and diurnal fluctuation in both eyes.

  • 5

    The report suggests a temporal association between clopidogrel and IOP dysregulation, but lacks definitive evidence of a drug-induced effect.

Original Source(s)

Symptomatic intraocular pressure dysregulation during clopidogrel exposure after patent foramen ovale closure in a patient with ocular hypertension and angle crowding: a Case Report

  • by Faxue Li, Rongbo Yu, Xuan Guo, Wenyi Ji, Qiang Wu

  • July 16, 2026

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