Emapunil attenuates ulcerative colitis by suppressing Z-DNA binding protein 1 driven pyroptosis and pro-inflammatory polarization in macrophages - Takeaways - MDSpire

Emapunil attenuates ulcerative colitis by suppressing Z-DNA binding protein 1 driven pyroptosis and pro-inflammatory polarization in macrophages

  • By

  • Shenghao Xv

  • Jie Hao

  • Sanhua Deng

  • Zhengyin Zhang

  • Runshu Wang

  • Jianbin Yin

  • Peisheng Chen

  • Fengjian He

  • Qianqian Peng

  • Fang Xie

  • Erwei Sun

  • Shimin Zheng

  • May 26, 2026

  • 0 min

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  • 1

    Emapunil reduces ulcerative colitis severity by inhibiting ZBP1-mediated pyroptosis and macrophage inflammatory polarization.

  • 2

    ZBP1 is significantly upregulated in macrophages from ulcerative colitis patients, contributing to inflammation and barrier damage.

  • 3

    Overexpression of ZBP1 activates the NF-κB pathway, induces macrophage pyroptosis, and impairs intestinal barrier integrity.

  • 4

    Emapunil targets TSPO to downregulate ZBP1, suppress macrophage pyroptosis, and preserve intestinal barrier function in mice.

  • 5

    The study suggests Emapunil as a potential therapeutic strategy for ulcerative colitis by modulating ZBP1 in macrophages.

Original Source(s)

Emapunil attenuates ulcerative colitis by suppressing Z-DNA binding protein 1 driven pyroptosis and pro-inflammatory polarization in macrophages

  • by Shenghao Xv, Jie Hao, Sanhua Deng, Zhengyin Zhang, Runshu Wang, Jianbin Yin, Peisheng Chen, Fengjian He, Qianqian Peng, Fang Xie, Erwei Sun, Shimin Zheng

  • May 26, 2026

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