IDSA updates guidance for antimicrobial-resistant gram-negative infections

"Determining how best to place and use these agents requires weighing multiple factors and is a constantly evolving science."

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The IDSA updated its guidance on antimicrobial-resistant gram-negative infections, addressing six major pathogen groups.
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The guidance emphasizes the importance of susceptibility testing and reassessing treatment based on the organism's susceptibility profile.
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Preferred therapies vary by resistance mechanism, with carbapenems recommended for invasive ESBL-E infections outside the urinary tract.
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Newer beta-lactam agents are suggested for difficult-to-treat infections, with specific preferences based on infection type and resistance.
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The guidance aims to assist clinicians in making informed treatment decisions amid evolving antimicrobial resistance.

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