Initial specialist validation of clinical decision support recommendations from a machine learning-enabled digital cognitive assessment

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The Linus Health Core Cognitive Evaluation (CCE) integrates digital tools to enhance cognitive impairment detection in primary care.
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A study involving five neurologists assessed the appropriateness of CCE-generated clinical decision support recommendations.
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All cognitive-impairment recommendations from the CCE met the appropriateness threshold, indicating their clinical relevance.
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Moderate agreement among experts was found, highlighting variability in recommendations for borderline cognitive concerns.
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Findings support the initial content validity of CCE's recommendations and emphasize the need for further refinement in low-risk pathways.

Frontiers In Neurology

by Ali Jannati, Claudio Toro-Serey, Marissa Ciesla, Emma Chen, David Bates, John Showalter, Sean Tobyne, Alvaro Pascual-Leone
June 17, 2026

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