Feeding the gut-immune axis: dietary, prebiotic, and probiotic strategies to target persistent inflammation in ART-treated HIV: a narrative review - Takeaways - MDSpire
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Nourishing the Gut-Immune Connection: Dietary, Prebiotic, and Probiotic Approaches to Address Chronic Inflammation in HIV Patients Under Antiretroviral Therapy: A Narrative Review

  • By

  • Aaron A. Fletcher

  • Ziad Koberssy

  • Joviane Daher

  • Nicolas Moussallem

  • Grace A. McComsey

  • July 17, 2026

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  • 1

    People living with HIV experience chronic inflammation due to gut dysbiosis and microbial translocation, despite antiretroviral therapy.

  • 2

    Short-chain fatty acids, particularly butyrate, play a crucial role in modulating immune responses and maintaining gut barrier integrity.

  • 3

    Probiotics, prebiotics, and dietary interventions have shown potential in reducing inflammatory biomarkers in people living with HIV.

  • 4

    The Mediterranean diet and omega-3 fatty acids are identified as underexplored dietary approaches that may influence gut microbiota and inflammation.

  • 5

    There is a need for more randomized trials to evaluate the effectiveness of dietary patterns and microbiome-targeted therapies in HIV patients.

Original Source(s)

Feeding the gut-immune axis: dietary, prebiotic, and probiotic strategies to target persistent inflammation in ART-treated HIV: a narrative review

  • by Aaron A. Fletcher, Ziad Koberssy, Joviane Daher, Nicolas Moussallem, Grace A. McComsey

  • July 17, 2026

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