Case Report: Rapid improvement with upadacitinib in a case of paradoxical skin lesions associated with SAPHO syndrome - Takeaways - MDSpire

Case Report: Rapid improvement with upadacitinib in a case of paradoxical skin lesions associated with SAPHO syndrome

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SAPHO syndrome is a rare autoinflammatory disorder characterized by osteoarticular and cutaneous involvement.
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Paradoxical skin lesions can occur during treatment with TNF-α inhibitors in patients with SAPHO syndrome.
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A 42-year-old man with SAPHO syndrome showed significant improvement in skin lesions after switching to upadacitinib.
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Upadacitinib treatment resulted in sustained control of musculoskeletal symptoms without adverse events.
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JAK inhibitors like upadacitinib may offer a therapeutic option for TNF-α inhibitor-induced skin lesions in SAPHO syndrome.

Frontiers In Immunology

Frontiers In Immunology

Frontiers In Medicine

Frontiers In Medicine

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