Cardiovascular Symptoms in Long COVID Linked to Endothelial and Cardiac Dysfunction via Dysregulation of the ADMA–DDAH–NOx Pathway - Takeaways - MDSpire

Cardiovascular Symptoms in Long COVID Linked to Endothelial and Cardiac Dysfunction via Dysregulation of the ADMA–DDAH–NOx Pathway

  • By

  • Mohamed Saad Rakab

  • Imaduddin Mirza

  • Mohamed M. Ali

  • Ammar Khan

  • Dawood Darbar

  • Abeer M. Mahmoud

  • April 21, 2026

  • 0 min

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  • 1

    PASC+ individuals exhibited significantly higher inflammatory and thrombotic markers compared to controls and PASC− participants.

  • 2

    The ADMA–DDAH–NOx pathway was dysregulated in PASC+, leading to impaired endothelial function and cardiac involvement.

  • 3

    PASC+ participants had lower nitric oxide levels and higher asymmetric dimethylarginine (ADMA) compared to other groups.

  • 4

    Endothelial function was notably impaired in PASC+, as indicated by reduced brachial and microvascular flow-mediated dilation.

  • 5

    These findings suggest that targeting the ADMA–DDAH–NOx axis may offer therapeutic potential for managing cardiovascular symptoms in long COVID.

Original Source(s)

Cardiovascular Symptoms in Long COVID Linked to Endothelial and Cardiac Dysfunction via Dysregulation of the ADMA–DDAH–NOx Pathway

  • by Mohamed Saad Rakab, Imaduddin Mirza, Mohamed M. Ali, Ammar Khan, Dawood Darbar, Abeer M. Mahmoud

  • April 21, 2026

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