Tracing the stemness and malignant transition in a heritable colorectal cancer Lynch Syndrome by single-cell RNA-seq analysis

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Lynch Syndrome is characterized by germline mutations in DNA mismatch repair genes, leading to a high risk of colorectal cancer.
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Single-cell RNA sequencing revealed increased cancer stem cells and specific biomarkers in the epithelium of Lynch Syndrome patients.
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Carcinoma tissues showed significantly higher immune cell infiltration and DNA repair activity compared to para-carcinoma tissues.
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The mutation burden in Lynch Syndrome patients was found to be significantly elevated compared to healthy controls.
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This study provides a comprehensive single-cell atlas of Lynch Syndrome, detailing alterations in cancer stem cell markers and tumor immunity.

Frontiers In Immunology

by Junfeng Xu, Jianlin Zhang, Yuhang Li, Zhiqin Wang, Qianru Li, Aijun Liu, Jianqiu Sheng, Ge Dong, Lang Yang, Zhigang Cai
May 25, 2026

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