Secondary hemophagocytic lymphohistiocytosis in pediatric patients: a single-center experience

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Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome often triggered by infections in children.
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In a study of 16 children, infections were the most common trigger for secondary HLH, accounting for 56.3% of cases.
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Clinical features at presentation included fever, cytopenias, splenomegaly, and hyperferritinemia, with 93.8% showing fever.
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Thirteen out of sixteen patients achieved complete remission, and the overall survival rate was 87.5% in this cohort.
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Metabolic disease and Langerhans cell histiocytosis were associated with refractory disease and mortality in pediatric HLH.

Frontiers In Pediatrics

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