Malignant reninoma with pulmonary metastasis and ATRX mutation treated with olaparib: a case report of specialized treatment - Takeaways - MDSpire

Malignant reninoma with pulmonary metastasis and ATRX mutation treated with olaparib: a case report of specialized treatment

  • By

  • Guo run Zi

  • Da-jiang Zhang

  • Dong-Lin He

  • Run-lin Feng

  • Chang-xing Ke

  • May 4, 2026

  • 0 min

Share

  • 1

    A 32-year-old woman with malignant reninoma and an ATRX mutation was initially misdiagnosed and underwent radical nephrectomy.

  • 2

    The patient experienced local recurrence and pulmonary metastasis, leading to a revised diagnosis of malignant juxtaglomerular cell tumor.

  • 3

    Olaparib therapy resulted in the resolution of the renal recurrent tumor, but pancreatic lesions and pulmonary metastasis progressed.

  • 4

    Next-generation sequencing identified an ATRX mutation, highlighting the importance of molecular targets in managing rare tumors.

  • 5

    This case underscores the need for combination therapies to address tumor heterogeneity and drug resistance in malignant reninoma.

Original Source(s)

Malignant reninoma with pulmonary metastasis and ATRX mutation treated with olaparib: a case report of specialized treatment

  • by Guo run Zi, Da-jiang Zhang, Dong-Lin He, Run-lin Feng, Chang-xing Ke

  • May 4, 2026

Related Content

Differentiation of hepatocellular carcinoma from hepatic hemangioma using diffusion-derived vessel density map-based radiomics features

Management of toxicities from antibody – drug conjugates in breast cancer

Case Report: First description of an intracranial “NET” in ROHHAD syndrome; time to rename to the ROHHAD-NeCT syndrome?