Construction of a nomogram combining CT and serum markers for predicting macrolide resistance gene mutation status in pediatric Mycoplasma pneumoniae pneumonia

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A nomogram was developed to predict macrolide resistance gene mutations in pediatric Mycoplasma pneumoniae pneumonia using CT imaging and serum biomarkers.
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Children with macrolide-resistant pneumonia exhibited longer fever duration, increased hospital stays, and higher rates of respiratory distress compared to macrolide-sensitive cases.
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Elevated serum levels of CRP, D-dimer, NLR, PCT, IL-6, and LAR were significant indicators of macrolide resistance in the studied pediatric population.
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CT imaging revealed distinct patterns in lung involvement, with findings such as lobar consolidation and bilateral involvement correlating with macrolide resistance.
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The nomogram demonstrated excellent predictive performance with an area under the curve of 0.869, aiding early clinical decision-making for antibiotic therapy.

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