The potential of laminar functional MRI in refining the understanding of epilepsy in humans - Takeaways - MDSpire

The potential of laminar functional MRI in refining the understanding of epilepsy in humans

  • By

  • Fraser Aitken

  • Joel S Winston

  • Jonathan O’Muircheartaigh

  • David W Carmichael

  • September 3, 2025

  • 0 min

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  • 1

    Drug-resistant epilepsy affects 25%-30% of patients, highlighting the limitations of current antiseizure medications.

  • 2

    Antiseizure medications primarily target nano-scale structures but are assessed at the macro-scale, creating a disconnect in understanding.

  • 3

    Cortical microcircuits, particularly deep cortical layers, play a crucial role in seizure generation and propagation.

  • 4

    Laminar fMRI can provide non-invasive insights into layer-specific mechanisms of seizure activity in humans.

  • 5

    Improving our understanding of epilepsy through laminar fMRI may enhance surgical targeting and the efficacy of future treatments.

Original Source(s)

The potential of laminar functional MRI in refining the understanding of epilepsy in humans

  • by Fraser Aitken, Joel S Winston, Jonathan O’Muircheartaigh, David W Carmichael

  • September 3, 2025

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