Comparative accuracy of 1-hour post-load plasma glucose, glycated albumin, and conventional glycemic measures for the diagnosis of type 2 diabetes mellitus: a systematic review and network meta-analysis - Takeaways - MDSpire

Comparative accuracy of 1-hour post-load plasma glucose, glycated albumin, and conventional glycemic measures for the diagnosis of type 2 diabetes mellitus: a systematic review and network meta-analysis

  • By

  • Jianzhou Tian

  • Ping Yuan

  • Liguo Tan

  • Youen Zhang

  • Jianing Wang

  • Ziheng Cui

  • Baopeng Tang

  • Jun Shen

  • July 8, 2026

  • 0 min

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  • 1

    The study systematically compared the diagnostic performance of 1-h PG, GA, FPG, HbA1c, and a combined strategy for identifying T2DM.

  • 2

    A total of 78 studies with 183,902 participants were included in the network meta-analysis evaluating these diagnostic measures.

  • 3

    1-h PG demonstrated the highest sensitivity (0.87) and lowest negative likelihood ratio (0.15) among the diagnostic indicators assessed.

  • 4

    FPG exhibited the highest specificity (0.96) and positive likelihood ratio (12.63), indicating its strong performance in correctly identifying non-diabetic individuals.

  • 5

    The findings suggest that while 1-h PG is effective for diagnosing T2DM, the results should be interpreted cautiously due to heterogeneity across studies.

Original Source(s)

Comparative accuracy of 1-hour post-load plasma glucose, glycated albumin, and conventional glycemic measures for the diagnosis of type 2 diabetes mellitus: a systematic review and network meta-analysis

  • by Jianzhou Tian, Ping Yuan, Liguo Tan, Youen Zhang, Jianing Wang, Ziheng Cui, Baopeng Tang, Jun Shen

  • July 8, 2026

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