Discovery of a resistant cohort to acute kidney injury: insights from patients with septic shock - Takeaways - MDSpire

Discovery of a resistant cohort to acute kidney injury: insights from patients with septic shock

  • By

  • Dana Y. Fuhrman

  • Towia A. Libermann

  • Neil A. Hukriede

  • Luca Molinari

  • Samir M. Parikh

  • John A. Kellum

  • October 8, 2025

  • 0 min

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  • 1

    Acute kidney injury (AKI) significantly increases morbidity and mortality in critically ill patients, particularly those with sepsis.

  • 2

    The study aimed to identify a subset of septic shock patients who exhibit AKI resistance despite high kidney stress biomarkers.

  • 3

    AKI resistance was defined by high levels of [TIMP-2]•[IGFBP7] without meeting KDIGO criteria for AKI or showing increased KIM-1.

  • 4

    The research utilized data from the ProCESS trial, analyzing urine samples for biomarkers at 6 hours post-resuscitation.

  • 5

    Primary outcomes included 30-day survival and ICU length of stay, comparing AKI-resistant patients to those with AKI and reduced AKI risk.

Original Source(s)

Discovery of a resistant cohort to acute kidney injury: insights from patients with septic shock

  • by Dana Y. Fuhrman, Towia A. Libermann, Neil A. Hukriede, Luca Molinari, Samir M. Parikh, John A. Kellum

  • October 8, 2025

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