The predictive value of platelet parameters for the response to initial 131I therapy in patients with differentiated thyroid cancer

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The study evaluated the predictive value of platelet parameters in 365 patients with differentiated thyroid cancer undergoing initial 131I therapy.
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Mean platelet volume (MPV) was found to be independently and negatively associated with non-excellent treatment response after adjusting for confounding factors.
3

The optimal cutoff value for MPV to predict non-excellent response was determined to be 9.95 fL, with a sensitivity of 0.595 and specificity of 0.657.
4

The area under the curve (AUC) for MPV's predictive value for treatment response was calculated to be 0.664, indicating moderate predictive ability.
5

The findings suggest that MPV may assist in identifying patients with poor treatment response to 131I therapy, but should not be the sole basis for clinical decisions.

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