Mapping Neurodegeneration with Spatial Glycoproteomics
Combined proteomic and glycomic profiling reveals molecular signatures of Alzheimer’s and Lewy body disease
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A spatial mass spectrometry workflow was developed to analyze brain proteins and sugars on microscope slides.
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The method enhances molecular coverage, allowing deeper analysis of glycosylated proteins linked to neurodegeneration.
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The study identified over 4,000 proteins, revealing significant molecular differences associated with aging and neurodegenerative diseases.
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Altered extracellular matrix proteins and reduced chondroitin sulfate glycans were linked to Alzheimer’s disease with Lewy body pathology.
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The researchers aim to support biomarker discovery and improve diagnosis and treatments through this high-resolution profiling technique.
