A Case of Amphotericin B-Resistant Cryptococcus laurentii Meningitis Complicated by Pulmonary Tuberculosis in a Patient with Pauci-Immune Crescentic Glomerulonephritis Due to MPO ANCA Vasculitis in Nepal - Takeaways - MDSpire

A Case of Amphotericin B-Resistant Cryptococcus laurentii Meningitis Complicated by Pulmonary Tuberculosis in a Patient with Pauci-Immune Crescentic Glomerulonephritis Due to MPO ANCA Vasculitis in Nepal

  • By

  • Rabin Nepali

  • Jyoti Kayastha

  • January 20, 2026

  • 0 min

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  • 1

    A 17-year-old male with pauci-immune crescentic glomerulonephritis developed amphotericin B-resistant Cryptococcus laurentii meningitis and pulmonary tuberculosis.

  • 2

    Intensive immunosuppression for ANCA vasculitis significantly increases the risk of opportunistic infections, complicating patient management.

  • 3

    Cryptococcus laurentii, a rare pathogen, is increasingly recognized in immunocompromised patients, highlighting diagnostic and therapeutic challenges.

  • 4

    The patient was treated with liposomal amphotericin B and fluconazole, but resistance to amphotericin B necessitated a switch to fluconazole alone.

  • 5

    Following antitubercular therapy, the patient's respiratory symptoms improved, and he was discharged with stable renal function and no new complaints.

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