What Causes Metastasis in Deadly Eye Cancer?
Gene expression profiling sheds new light on malignant transformation in uveal melanoma
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Uveal melanoma (UM) is the most common primary intraocular malignancy in adults, with a high risk of metastatic death despite local control.
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A multicenter study highlights gene expression profiling as superior to mutation analysis for risk stratification in UM.
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Mutations in BAP1, SF3B1, and EIF1AX correlate with high, intermediate, and low metastatic risk, respectively.
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Small tumors are often low-risk and may represent early evolutionary stages before full malignant transformation.
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The study emphasizes the importance of integrated molecular testing to differentiate between indolent and aggressive UM lesions.
