Infection incidence, timing, and predictors in newly diagnosed multiple myeloma: a real-world retrospective cohort study

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Infections occurred in 50.9% of newly diagnosed multiple myeloma patients, peaking during the first three months of induction therapy.
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Pneumonia was the most common infection, with gram-negative bacteria like Escherichia coli being the most prevalent pathogens identified.
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Advanced ISS stage, diabetes mellitus, and chronic kidney disease were identified as independent risk factors for infections in multiple myeloma patients.
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Lymphocyte levels significantly decreased during febrile episodes, suggesting a potential link to immune function in infection susceptibility.
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The study emphasizes the need for risk-adjusted infection prevention strategies based on clinical indicators during the early treatment phase.

Frontiers In Medicine

by Ozlem Candan, Narmin Naghizada, Tekin Tuncel, Beyza Melek Palaz, Mustafa Alperen Tunc, Derya Demirtas, Ahmet Mert Yanik, Arda Bayar, Secil Salim, Fatma Temiz, Ceren Uzunoglu Guren, Fatma Arıkan, Meral Ulukoylu Menguc, Asu Fergun Yilmaz, Isik Atagunduz, Zekaver Odabası, Tayfur Toptas, Ayse Tulin Tuglular
May 14, 2026

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