Investigating Associations Between Medications and Suicide Risk: A Retrospective Analysis from 2004 to 2024 - Takeaways - MDSpire

Investigating Associations Between Medications and Suicide Risk: A Retrospective Analysis from 2004 to 2024

  • By

  • Zhilan Zhou

  • Junlin Diao

  • Jie Wan

  • Lurong Yu

  • Limei Liu

  • April 29, 2026

  • 0 min

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  • 1

    The study analyzed 247,657 reports of suicide-related adverse events (SAEs) involving 193 drugs from the FAERS database between 2004 and 2024.

  • 2

    Central nervous system medications were most associated with SAEs, often occurring early in the treatment process.

  • 3

    Montelukast, isotretinoin, and sertraline were the top drugs linked to SAEs in individuals under 18 years old.

  • 4

    Hydrocodone/acetaminophen showed a significantly higher risk of SAEs in individuals aged 65 and older.

  • 5

    The findings highlight the need for targeted drug safety monitoring and suggest combining datasets for improved risk assessment.

Original Source(s)

Investigating Associations Between Medications and Suicide Risk: A Retrospective Analysis from 2004 to 2024

  • by Zhilan Zhou, Junlin Diao, Jie Wan, Lurong Yu, Limei Liu

  • April 29, 2026

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