Type 3 innate lymphoid cells dominate the ILC compartment in endstage lung disease - Takeaways - MDSpire

Type 3 innate lymphoid cells dominate the ILC compartment in endstage lung disease

  • By

  • Olga Halle

  • Jan-Niklas Falke

  • Claudia Kessemeier

  • Khatuna Lobjanidze

  • Emily Fuchshuber

  • Sean Brüske

  • Svenja Gaedcke

  • Marina Schumacher

  • Londa Dähne

  • Jonas Knaup

  • Maresa Borghorst

  • Sophia Pallenberg

  • Melanie Albrecht

  • Adan Chari Jirmo

  • Jana Bergmann

  • Michelle Paulsen

  • Danny Jonigk

  • Peter Braubach

  • Anna-Maria Dittrich

  • June 10, 2026

  • 0 min

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  • 1

    Type 3 innate lymphoid cells (ILCs) dominate the ILC population in lungs and lymph nodes of patients with advanced lung diseases.

  • 2

    Type 1 ILCs are the major population in healthy lung tissue, contrasting with the predominance of type 3 ILCs in endstage lung disease.

  • 3

    In clinically stable cystic fibrosis patients, type 2 ILCs are found at increased frequencies compared to healthy controls.

  • 4

    Type 2 ILC frequency changes persist for up to 24 months in cystic fibrosis patients receiving CFTR modulator therapy.

  • 5

    The study highlights unique immunological aspects of chronic lung disease that are difficult to address with disease-modifying treatments.

Original Source(s)

Type 3 innate lymphoid cells dominate the ILC compartment in endstage lung disease

  • by Olga Halle, Jan-Niklas Falke, Claudia Kessemeier, Khatuna Lobjanidze, Emily Fuchshuber, Sean Brüske, Svenja Gaedcke, Marina Schumacher, Londa Dähne, Jonas Knaup, Maresa Borghorst, Sophia Pallenberg, Melanie Albrecht, Adan Chari Jirmo, Jana Bergmann, Michelle Paulsen, Danny Jonigk, Peter Braubach, Anna-Maria Dittrich

  • June 10, 2026

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