Inflammation, oxidative stress, matrix metalloproteinases and DNA damage in diabetic polyneuropathy and neuropathic pain - Takeaways - MDSpire

The Role of Inflammation, Oxidative Stress, Matrix Metalloproteinases, and DNA Damage in Diabetic Polyneuropathy and Associated Neuropathic Pain

  • By

  • Tugce Ozdemir Gultekin

  • Elif Gokcal

  • Huri Demirci

  • Asli Yaman Kula

  • Cigdem Deniz

  • Abdurrahim Kocyigit

  • Talip Asil

  • Azize Esra Gursoy

  • July 20, 2026

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  • 1

    Diabetic polyneuropathy (DPNP) is a common complication of type 2 diabetes, leading to significant morbidity and impaired quality of life.

  • 2

    The study involved 108 patients with type 2 diabetes and 42 healthy controls, assessing various biomarkers related to inflammation and oxidative stress.

  • 3

    Significantly elevated levels of IL-6, TNF-α, IL-1β, MMP-9, MMP-10, oxidative stress index, and DNA damage were found in diabetic patients compared to healthy controls.

  • 4

    Increased levels of MMP-9, MMP-10, and oxidative stress index were independently associated with the presence of DPNP in diabetic patients.

  • 5

    The findings suggest a complex interplay of inflammation, oxidative stress, and matrix metalloproteinase activation in diabetic neuropathy.

Original Source(s)

Inflammation, oxidative stress, matrix metalloproteinases and DNA damage in diabetic polyneuropathy and neuropathic pain

  • by Tugce Ozdemir Gultekin, Elif Gokcal, Huri Demirci, Asli Yaman Kula, Cigdem Deniz, Abdurrahim Kocyigit, Talip Asil, Azize Esra Gursoy

  • July 20, 2026

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