Correlation of Rv0191 and Rv3008 Efflux Pump Gene Overexpression with Pyrazinamide Resistance in Multidrug-Resistant Mycobacterium tuberculosis: A Multi-Center Investigation - Takeaways - MDSpire

Correlation of Rv0191 and Rv3008 Efflux Pump Gene Overexpression with Pyrazinamide Resistance in Multidrug-Resistant Mycobacterium tuberculosis: A Multi-Center Investigation

  • By

  • Mohammad Hashemzadeh

  • Sadegh Hamid

  • Azar Dokht Khosravi

  • Saman Soleimanpour

  • Mohammad Savari

  • February 6, 2026

  • 0 min

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  • 1

    Tuberculosis remains a leading global health issue, with approximately 10 million infections and 1.6 million deaths reported in 2023.

  • 2

    Efflux pumps Rv0191 and Rv3008 are significantly associated with pyrazinamide resistance in multidrug-resistant Mycobacterium tuberculosis.

  • 3

    Overexpression of Rv0191 and Rv3008 contributes to reduced efficacy of pyrazinamide, despite pncA mutations being the most common resistance mechanism.

  • 4

    The study involved 40 clinical isolates of M. tuberculosis from two provinces in Iran, focusing on gene expression and drug susceptibility.

  • 5

    Findings suggest that alternative resistance mechanisms, including efflux pump overexpression, play a crucial role in pyrazinamide resistance.

Original Source(s)

Correlation of Rv0191 and Rv3008 Efflux Pump Gene Overexpression with Pyrazinamide Resistance in Multidrug-Resistant Mycobacterium tuberculosis: A Multi-Center Investigation

  • by Mohammad Hashemzadeh, Sadegh Hamid, Azar Dokht Khosravi, Saman Soleimanpour, Mohammad Savari

  • February 6, 2026

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