From inflammatory initiation to fibrotic remodeling: mechanisms and precision therapeutic strategies in otorhinolaryngologic involvement of IgG4-related disease - Takeaways - MDSpire

From inflammatory initiation to fibrotic remodeling: mechanisms and precision therapeutic strategies in otorhinolaryngologic involvement of IgG4-related disease

  • By

  • Minfang Wang

  • Yongcai Weng

  • Jun Ma

  • Yong Wu

  • June 25, 2026

  • 0 min

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  • 1

    IgG4-related disease (IgG4-RD) is a systemic fibroinflammatory disorder with significant underdiagnosis in clinical practice.

  • 2

    The disease commonly affects the head and neck region, including major salivary glands and lacrimal glands.

  • 3

    The immunopathogenesis of IgG4-RD involves CD4+ cytotoxic T lymphocytes and a Th2-skewed cytokine environment promoting IgG4 class-switching.

  • 4

    Glucocorticoids are the standard first-line treatment for IgG4-RD, but high relapse rates limit their effectiveness.

  • 5

    Rituximab and Inebilizumab have shown efficacy in treating refractory IgG4-RD, while Dupilumab requires further validation.

Original Source(s)

From inflammatory initiation to fibrotic remodeling: mechanisms and precision therapeutic strategies in otorhinolaryngologic involvement of IgG4-related disease

  • by Minfang Wang, Yongcai Weng, Jun Ma, Yong Wu

  • June 25, 2026

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