Codonopsis pilosula polysaccharide attenuates the inflammatory response in macrophages induced by Brucella abortus outer membrane protein 19 via regulating ATP2A1 to modulate cell adhesion and calcium signaling - Takeaways - MDSpire

Codonopsis pilosula polysaccharide attenuates the inflammatory response in macrophages induced by Brucella abortus outer membrane protein 19 via regulating ATP2A1 to modulate cell adhesion and calcium signaling

  • By

  • Xuxu Wang

  • Zhiyong Zhou

  • Nan Zhang

  • Ziying Zhang

  • Xingyue Qi

  • Xingguang Zhang

  • Zhiguo Gong

  • Wuzhi Zhong

  • Kun Liu

  • Yuan Shen

  • June 2, 2026

  • 0 min

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  • 1

    Codonopsis pilosula polysaccharides (CPPS) significantly reduce macrophage inflammation caused by Brucella abortus outer membrane protein 19 (OMP19).

  • 2

    CPPS downregulate pro-inflammatory cytokines TNF-α and IL-6 while increasing the anti-inflammatory cytokine IL-10 in macrophages.

  • 3

    The study identifies ATP2A1 as a key gene regulated by CPPS, which modulates cell adhesion and calcium signaling in macrophages.

  • 4

    In vivo, CPPS alleviated tissue damage and reduced the expression of high mobility group box 1 protein (HMGB1) and adhesion proteins.

  • 5

    CPPS inhibit inflammatory signaling pathways, including SYK/FAK/AKT phosphorylation and PKC activation, enhancing macrophage phagocytosis.

Original Source(s)

Codonopsis pilosula polysaccharide attenuates the inflammatory response in macrophages induced by Brucella abortus outer membrane protein 19 via regulating ATP2A1 to modulate cell adhesion and calcium signaling

  • by Xuxu Wang, Zhiyong Zhou, Nan Zhang, Ziying Zhang, Xingyue Qi, Xingguang Zhang, Zhiguo Gong, Wuzhi Zhong, Kun Liu, Yuan Shen

  • June 2, 2026

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