Maternal immunization status and SARS-CoV-2 antibody transfer to neonates at birth - Takeaways - MDSpire

Maternal immunization status and SARS-CoV-2 antibody transfer to neonates at birth

  • By

  • J. Gómez-Carballo

  • R. González-Losa

  • L. Conde-Ferráez

  • C. Cen-Baas

  • N. Kantun-Moreno

  • H. Puerta-Guardo

  • J. A. Cruz-Cárdenas

  • M. E. G. Brunck

  • Y. Leal-Herrera

  • G. Valencia-Pacheco

  • M. García-Knight

  • G. Ayora-Talavera

  • July 1, 2026

  • 0 min

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  • 1

    A cohort study of 117 pregnant women assessed IgG antibodies against SARS-CoV-2 at delivery, revealing significant maternal antibody transfer to neonates.

  • 2

    95% of mothers had detectable IgG, with 87% of neonates acquiring antibodies trans placentally, indicating effective maternal immunization.

  • 3

    Hybrid immunity in mothers was found in 65.5% of cases and correlated with higher anti-RBD IgG levels in newborns compared to other immunity types.

  • 4

    Neutralizing antibodies in umbilical cord samples showed the highest capacity, positively correlating with IgG titers in mothers.

  • 5

    The study suggests that maternal vaccination combined with natural infection enhances passive immunity in neonates against SARS-CoV-2.

Original Source(s)

Maternal immunization status and SARS-CoV-2 antibody transfer to neonates at birth

  • by J. Gómez-Carballo, R. González-Losa, L. Conde-Ferráez, C. Cen-Baas, N. Kantun-Moreno, H. Puerta-Guardo, J. A. Cruz-Cárdenas, M. E. G. Brunck, Y. Leal-Herrera, G. Valencia-Pacheco, M. García-Knight, G. Ayora-Talavera

  • July 1, 2026

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