Risk factors for radiation pneumonitis following adjuvant radiotherapy for breast cancer: a retrospective cohort study

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A retrospective analysis of 811 breast cancer patients identified risk factors for radiation pneumonitis (RP) following adjuvant radiotherapy.
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Univariate analysis revealed tumor stage, chest wall + supraclavicular + internal mammary lymph node irradiation, and mean lung dose were significantly associated with RP.
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Multivariate analysis confirmed mean lung dose, number of chemotherapy cycles, and chest wall + supraclavicular + internal mammary lymph node irradiation as independent risk factors for RP.
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The predictive sensitivity and specificity for RP were 0.898 and 0.965, respectively, at a mean lung dose threshold of 12.70 Gy.
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Bootstrap internal validation confirmed the robustness of findings, emphasizing the need for stringent dosimetric constraints to minimize mean lung dose.

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