Acupuncture for premature ovarian insufficiency: a systemic neuroendocrine perspective

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Premature ovarian insufficiency (POI) is recognized as a systemic neuroendocrine condition affecting multiple bodily systems.
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Acupuncture may influence reproductive hormone regulation and has been associated with changes in ovarian reserve indicators and menstrual function.
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Current evidence on acupuncture's efficacy in POI is limited by small sample sizes, short follow-up durations, and methodological variability.
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POI involves dysregulation of the HPO axis, KNDy–GnRH network, and other systemic processes, highlighting its complexity beyond ovarian dysfunction.
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Further large-scale studies with standardized measures are needed to evaluate acupuncture's effectiveness and clarify its mechanisms in POI.

Frontiers In Endocrinology

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