Combination of quantitative MRI and laboratory markers for the detection and staging of metabolic dysfunction-associated steatotic liver disease - Takeaways - MDSpire

Combination of quantitative MRI and laboratory markers for the detection and staging of metabolic dysfunction-associated steatotic liver disease

  • By

  • Nienke P. M. Wassenaar

  • Koen C. van Son

  • Bas Voermans

  • Kirsi M. A. van Eekhout

  • Marian A. Troelstra

  • Stan Driessen

  • Anne Line Mak

  • Julia J. Witjes

  • Anne-Marieke van Dijk

  • Veera Houttu

  • Diona Zwirs

  • Elizabeth Shumbayawonda

  • Max Nieuwdorp

  • Michail Doukas

  • Joanne Verheij

  • Aart J. Nederveen

  • Oliver J. Gurney-Champion

  • Adriaan G. Holleboom

  • March 28, 2026

  • 0 min

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  • 1

    Approximately 30% of adults globally have metabolic dysfunction-associated steatotic liver disease (MASLD), increasing their risk of severe liver complications.

  • 2

    MASLD is characterized by fat accumulation in hepatocytes, often linked to metabolic risk factors like type 2 diabetes and obesity.

  • 3

    Quantitative MRI techniques (qMRI) provide non-invasive alternatives to liver biopsy for diagnosing and staging MASLD.

  • 4

    Combining qMRI with non-invasive biomarkers enhances diagnostic accuracy for identifying stages of MASLD, including fibrosis.

  • 5

    The study utilized data from the Amsterdam NAFLD-NASH cohort to assess the effectiveness of qMRI and other non-invasive tests in detecting MASLD.

Original Source(s)

Combination of quantitative MRI and laboratory markers for the detection and staging of metabolic dysfunction-associated steatotic liver disease

  • by Nienke P. M. Wassenaar, Koen C. van Son, Bas Voermans, Kirsi M. A. van Eekhout, Marian A. Troelstra, Stan Driessen, Anne Line Mak, Julia J. Witjes, Anne-Marieke van Dijk, Veera Houttu, Diona Zwirs, Elizabeth Shumbayawonda, Max Nieuwdorp, Michail Doukas, Joanne Verheij, Aart J. Nederveen, Oliver J. Gurney-Champion, Adriaan G. Holleboom

  • March 28, 2026

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