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1
The study involved 287 patients with systemic sclerosis, categorized by organ involvement including isolated SSc, ILD, and pulmonary hypertension.
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2
Dual-axis stratification using the Systemic Immune-Inflammation Index and D-dimer-to-Platelet Ratio identified high-risk patients with significantly increased mortality.
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3
K-means clustering revealed three distinct immune-inflammation-coagulation-fibrinolysis molecular endotypes with incomplete concordance to organ involvement.
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4
The multi-index prognostic score achieved an area under the curve of 0.747 for mortality prediction, outperforming traditional indices.
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5
The findings suggest that systemic network disequilibrium, rather than isolated pathway issues, drives adverse outcomes in systemic sclerosis.
