Autoimmune GFAP astrocytopathy with eosinophils on cerebrospinal fluid cytology and isolated spinal cord lesions on MRI: a case report - Takeaways - MDSpire

Autoimmune GFAP astrocytopathy with eosinophils on cerebrospinal fluid cytology and isolated spinal cord lesions on MRI: a case report

  • By

  • Dongdong Zhang

  • Yahan Song

  • Yongjie Bai

  • Junqiang Yan

  • Ruile Shen

  • June 16, 2026

  • 0 min

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  • 1

    Autoimmune GFAP astrocytopathy is characterized by GFAP-IgG positivity and presents with various neurological symptoms.

  • 2

    Isolated spinal cord lesions on MRI can indicate autoimmune GFAP astrocytopathy, even when brain MRI findings are normal.

  • 3

    Cerebrospinal fluid analysis in this case revealed eosinophils, which are rarely reported in autoimmune GFAP astrocytopathy.

  • 4

    The patient showed significant improvement after treatment with high-dose intravenous methylprednisolone and oral prednisone.

  • 5

    The presence of eosinophils in CSF may provide insights into the inflammatory profile and pathophysiology of autoimmune GFAP astrocytopathy.

Original Source(s)

Autoimmune GFAP astrocytopathy with eosinophils on cerebrospinal fluid cytology and isolated spinal cord lesions on MRI: a case report

  • by Dongdong Zhang, Yahan Song, Yongjie Bai, Junqiang Yan, Ruile Shen

  • June 16, 2026

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