Real-world graft utilization after CTN-1101: a registry-based analysis of haploidentical graft versus umbilical cord blood trends - Takeaways - MDSpire

Real-world graft utilization after CTN-1101: a registry-based analysis of haploidentical graft versus umbilical cord blood trends

  • By

  • Danh T. Tran

  • Ruyun Jin

  • Hong Zhu

  • Gabrielle Schmidt

  • Stephen R. Spellman

  • Karen K. Ballen

  • August 18, 2025

  • 0 min

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  • 1

    Haploidentical grafts showed better two-year overall survival compared to double umbilical cord blood in the CTN-1101 trial.

  • 2

    Real-world analysis indicated an increase in haploidentical transplants and a decrease in umbilical cord blood transplants from 2009 to 2019.

  • 3

    The study utilized data from 246 U.S. centers, focusing on adult recipients aged 18 to 70 who underwent specific types of HCT.

  • 4

    Demographic factors such as age, sex, and race/ethnicity were analyzed for their association with graft utilization trends.

  • 5

    The findings support the need for resource-intensive phase 3 trials to influence clinical practice in hematopoietic cell transplantation.

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