Resting motor threshold in navigated transcranial magnetic stimulation: relationship between inter-individual variance and distinct clinical and anatomical factors

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Navigated transcranial magnetic stimulation (nTMS) aids in preoperative planning by assessing motor networks in brain tumor patients.
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Resting motor threshold (RMT) is critical for TMS efficacy and patient safety, defined as the lowest stimulation to elicit a motor response.
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RMT shows significant variability influenced by factors like age, tumor characteristics, and medication use, particularly antiepileptic drugs.
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This study analyzed RMT in over 600 brain tumor patients, focusing on clinical and anatomical factors affecting cortical excitability.
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The findings aim to refine nTMS-based cortical mapping, enhancing its clinical application in neurosurgery.

Acta Neurochirurgica

by Felipe Monte Santo, Heike Schneider, Tizian Rosenstock, Ismael Moser, Maren Denker, Peter Vajkoczy, Thomas Picht, Melina Engelhardt
December 1, 2025

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