Thrombectomy for Acute Stroke Due to Medium Vessel Occlusion Across Perfusion Mismatch Profiles: A Post Hoc - Takeaways - MDSpire
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Thrombectomy for Acute Stroke From Medium Vessel Occlusion Across Perfusion Mismatch Patterns: A Post Hoc Analysis

  • By

  • Umberto Pensato

  • Gunjan Jindal

  • William Diprose

  • Aravind Ganesh

  • Pattarawut Charatpangoon

  • Ethan MacDonald

  • Alexander Stebner

  • Salome Bosshart

  • Dar Dowlatshahi

  • David Volders

  • James Kennedy

  • Markus Möhlenbruch

  • Brian H. Buck

  • Shahid Nimjee

  • Thomas Booth

  • Mouhammad Jumaa

  • Jai J. Shankar

  • Franziska Dorn

  • Andrew M. Demchuk

  • Mayank Goyal

  • Michael D. Hill

  • Johanna M. Ospel

  • ESCAPE-MEVO Investigators

  • Jennifer Mandzia

  • Sachin Pandey

  • Jesse Klostranec

  • Lissa Peeling

  • Joanna Schaafsma

  • Timo Krings

  • Atif Zafar

  • Ravinder-Jeet Singh

  • Demetrios Sahlas

  • Thalia Field

  • Richard Swartz

  • Pual (Inder) Singh

  • Koji Ebersole

  • Negar Asdashi

  • Dileep Yavagal

  • Reade De Leacy

  • George Lopez

  • Babak Jahromi

  • Ronald Budzik

  • Seon-Kyu Lee

  • Eric Sauvageau

  • Adewumi Amole

  • Maxim Mokin

  • Mchael Levitt

  • Jason Tarpley

  • Albert Yoo

  • Michael Chen

  • Thanhn Nguyen

  • Santiago Ortega-Gutierrez

  • Adnan Siddiqui

  • Fabio Settecase

  • Thien Huynh

  • Tufail Patankar

  • Levansri Makalanda

  • Paul Burns

  • Changez Jadun

  • Aubrey Smith

  • Kyriakos Lobotesis

  • Rob Crossley

  • Robert Lenthall

  • Thant Hlaing

  • Ayokunle Ogungbemi

  • Liqun Zhang

  • Richard Marigold

  • Yogish Joshi

  • Richard Perry

  • Christian Hametner

  • Sven Poli

  • Joerg Berrouschot

  • Christian Taschner

  • Arno Reich

  • Hauke Scheider

  • Sandor Nardai

  • Gabor Lenzser

  • October 13, 2026

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  • 1

    Three randomized trials found no advantage of endovascular thrombectomy over medical therapy for medium vessel occlusion stroke.

  • 2

    This post hoc analysis used ESCAPE-MeVO trial data to examine whether perfusion mismatch profiles were associated with outcomes or modified the effect of thrombectomy.

  • 3

    The analysis included trial participants with interpretable baseline perfusion imaging and an available 90-day modified Rankin Scale score.

  • 4

    Perfusion mismatch volume was calculated as the difference between tissue with Tmax greater than 6 seconds and ischemic core with relative cerebral blood flow below 30%.

  • 5

    The primary outcome was the ordinal 90-day modified Rankin Scale score; secondary outcomes included 90-day functional status and 24-hour infarct volume.

Original Source(s)

Thrombectomy for Acute Stroke Due to Medium Vessel Occlusion Across Perfusion Mismatch Profiles: A Post Hoc

  • by Umberto Pensato, Gunjan Jindal, William Diprose, Aravind Ganesh, Pattarawut Charatpangoon, Ethan MacDonald, Alexander Stebner, Salome Bosshart, Dar Dowlatshahi, David Volders, James Kennedy, Markus Möhlenbruch, Brian H. Buck, Shahid Nimjee, Thomas Booth, Mouhammad Jumaa, Jai J. Shankar, Franziska Dorn, Andrew M. Demchuk, Mayank Goyal, Michael D. Hill, Johanna M. Ospel, ESCAPE-MEVO Investigators, Jennifer Mandzia, Sachin Pandey, Jesse Klostranec, Lissa Peeling, Joanna Schaafsma, Timo Krings, Atif Zafar, Ravinder-Jeet Singh, Demetrios Sahlas, Thalia Field, Richard Swartz, Pual (Inder) Singh, Koji Ebersole, Negar Asdashi, Dileep Yavagal, Reade De Leacy, George Lopez, Babak Jahromi, Ronald Budzik, Seon-Kyu Lee, Eric Sauvageau, Adewumi Amole, Maxim Mokin, Mchael Levitt, Jason Tarpley, Albert Yoo, Michael Chen, Thanhn Nguyen, Santiago Ortega-Gutierrez, Adnan Siddiqui, Fabio Settecase, Thien Huynh, Tufail Patankar, Levansri Makalanda, Paul Burns, Changez Jadun, Aubrey Smith, Kyriakos Lobotesis, Rob Crossley, Robert Lenthall, Thant Hlaing, Ayokunle Ogungbemi, Liqun Zhang, Richard Marigold, Yogish Joshi, Richard Perry, Christian Hametner, Sven Poli, Joerg Berrouschot, Christian Taschner, Arno Reich, Hauke Scheider, Sandor Nardai, Gabor Lenzser

  • October 13, 2026

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