miR-142-5p promotes TSCM differentiation and suppresses progressive T-cell maturation via targeting PRKCB - Takeaways - MDSpire

miR-142-5p promotes TSCM differentiation and suppresses progressive T-cell maturation via targeting PRKCB

  • By

  • Hongqiong Wang

  • Shengfang Xia

  • Jia Chen

  • Huishan Zhong

  • Xianpei Zeng

  • Zitao Lu

  • Wenfeng Zhang

  • Fenglin Wu

  • May 18, 2026

  • 0 min

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  • 1

    miR-142-5p is highly expressed in TSCM cells and decreases during T-cell differentiation, influencing T-cell maturation.

  • 2

    Overexpression of miR-142-5p enhances early differentiation markers and promotes TSCM and TN cell proportions while reducing TEM/TEFF cells.

  • 3

    miR-142-5p directly targets PRKCB, leading to the suppression of late differentiation and effector function-related genes.

  • 4

    The study suggests that miR-142-5p could improve the persistence and efficacy of adoptive T-cell therapies by maintaining an early-differentiated phenotype.

  • 5

    Functional studies demonstrated that miR-142-5p overexpression promotes T-cell proliferation and reduces apoptosis and cytokine secretion.

Original Source(s)

miR-142-5p promotes TSCM differentiation and suppresses progressive T-cell maturation via targeting PRKCB

  • by Hongqiong Wang, Shengfang Xia, Jia Chen, Huishan Zhong, Xianpei Zeng, Zitao Lu, Wenfeng Zhang, Fenglin Wu

  • May 18, 2026

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