The duality of disease: the Alzheimer’s disease dilemma through the lens of nosos and asthenia

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Alzheimer's disease embodies a tension between biological pathology (nosos) and the lived experience of cognitive decline (asthenia).
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Historical concepts of nosos and asthenia highlight the evolution of disease definitions from symptom-based to mechanism-based classifications.
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Modern diagnostics allow for early identification of Alzheimer's pathology, emphasizing a shift towards biological definitions over clinical symptoms.
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A nosological approach enhances diagnostic precision, preventing misclassification of Alzheimer's disease and ensuring targeted research and treatment.
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Despite the focus on biological definitions, clinical symptoms remain crucial for patient care, caregiver burden, and treatment decisions.

Brain

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