IGFBP-1 is associated with IRS signaling upregulation and contributes to metabolic recovery post-Roux-en-Y bypass

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Increased IGFBP-1 levels after Roux-en-Y gastric bypass (RYGB) are linked to the upregulation of IRS-1 and downstream signaling components.
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RYGB significantly improved body weight, fasting blood glucose, and HOMA-IR in wild-type mice, indicating enhanced metabolic recovery.
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Histomorphometric analysis showed RYGB reversed multi-organ pathological changes in wild-type mice, but effects were limited in IGFBP-1 knockout mice.
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The study utilized wild-type and IGFBP-1 knockout mice to assess the role of IGFBP-1 in metabolic signaling post-surgery.
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Elevated IGFBP-1 is necessary for complete normalization of glucose homeostasis and multi-tissue repair following RYGB.

Frontiers In Endocrinology

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