CRS Trial Reveals Surgery Divide - Takeaways - MDSpire

CRS Trial Reveals Surgery Divide

MACRO qualitative study explores why patients differ in attitudes toward endoscopic sinus surgery.

  • By

  • Jess Allerton

  • March 18, 2026

  • 3 min

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  • 1

    The MACRO trial compared endoscopic sinus surgery, clarithromycin, and placebo in patients with chronic rhinosinusitis across 21 centers in England and Scotland.

  • 2

    Endoscopic sinus surgery showed greater improvement in patient-reported outcomes compared to clarithromycin or placebo at 6 months.

  • 3

    Patients expressed varied views on surgery, with some seeing it as a logical step, while others were concerned about risks and recovery.

  • 4

    Postoperative experiences varied, with some patients reporting rapid relief and others facing complications or prolonged recovery.

  • 5

    Implementation of MACRO trial findings will require effective communication, shared decision-making, and adequate health system resources.

Original Source(s)

CRS Trial Reveals Surgery Divide

  • by Jess Allerton

  • March 18, 2026

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