CRS Trial Reveals Surgery Divide

MACRO qualitative study explores why patients differ in attitudes toward endoscopic sinus surgery.

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The MACRO trial compared endoscopic sinus surgery, clarithromycin, and placebo in patients with chronic rhinosinusitis across 21 centers in England and Scotland.
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Endoscopic sinus surgery showed greater improvement in patient-reported outcomes compared to clarithromycin or placebo at 6 months.
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Patients expressed varied views on surgery, with some seeing it as a logical step, while others were concerned about risks and recovery.
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Postoperative experiences varied, with some patients reporting rapid relief and others facing complications or prolonged recovery.
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Implementation of MACRO trial findings will require effective communication, shared decision-making, and adequate health system resources.

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