Impact of high-fat Western diet on chronic lymphocytic leukemia disease progression and gut microbiome profile in Eµ-TCL1 mice - Takeaways - MDSpire

Effects of a High-Fat Western Diet on Disease Progression and Gut Microbiome Alterations in Eµ-TCL1 Mouse Model of Chronic Lymphocytic Leukemia

  • By

  • Sydney A. Skupa

  • Jordan B. Hernandez

  • Audrey L. Smith

  • Erin M. Drengler

  • Jayesh Rai

  • Jianmin Pan

  • Anand K. Seth

  • Shesh N. Rai

  • Jonathan B. Clayton

  • Christopher R. D’Angelo

  • Dalia El-Gamal

  • July 21, 2026

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  • 1

    Mice on a high-fat Western diet had significantly shorter survival compared to those on a standard chow diet, regardless of sex.

  • 2

    The high-fat diet led to increased splenic involvement by chronic lymphocytic leukemia at the time of sacrifice.

  • 3

    Mice on the high-fat diet exhibited reduced alpha diversity and significant changes in gut microbiome community composition.

  • 4

    A larger change in alpha diversity correlated with higher disease burden and worse survival at four weeks post-engraftment.

  • 5

    The high-fat diet resulted in sustained increases in Akkermansia muciniphila and Bacteroidetes thetaiotaomicron in the gut microbiome.

Original Source(s)

Impact of high-fat Western diet on chronic lymphocytic leukemia disease progression and gut microbiome profile in Eµ-TCL1 mice

  • by Sydney A. Skupa, Jordan B. Hernandez, Audrey L. Smith, Erin M. Drengler, Jayesh Rai, Jianmin Pan, Anand K. Seth, Shesh N. Rai, Jonathan B. Clayton, Christopher R. D’Angelo, Dalia El-Gamal

  • July 21, 2026

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