25HC regulates the polarization of CD163+ macrophages in the immune microenvironment of triple-negative breast cancer through the interferon pathway - Takeaways - MDSpire

25HC regulates the polarization of CD163+ macrophages in the immune microenvironment of triple-negative breast cancer through the interferon pathway

  • By

  • Hongmei Zheng

  • Wenqin Huang

  • Panshi Zhang

  • Sudhanshu Bhushan

  • Xinhong Wu

  • Yalong Yang

  • May 28, 2026

  • 0 min

Share

  • 1

    25-hydroxycholesterol (25HC) is identified as a key regulator of macrophage polarization in triple-negative breast cancer (TNBC).

  • 2

    The study reveals an aberrantly activated interferon regulatory factor 7–cholesterol-25-hydroxylase–25HC axis in TNBC cells.

  • 3

    25HC inhibits CD163+ macrophage polarization, highlighting its role in the tumor immune microenvironment of TNBC.

  • 4

    This research provides novel insights into the immunometabolic mechanisms contributing to TNBC aggressiveness.

  • 5

    The findings suggest that targeting the 25HC pathway may offer a potential therapeutic strategy for TNBC.

Original Source(s)

25HC regulates the polarization of CD163+ macrophages in the immune microenvironment of triple-negative breast cancer through the interferon pathway

  • by Hongmei Zheng, Wenqin Huang, Panshi Zhang, Sudhanshu Bhushan, Xinhong Wu, Yalong Yang

  • May 28, 2026

Related Content

HiGATE: hierarchical graph attention for multi-scale tissue encoder in computational pathology

A patient with triple-negative breast cancer developed acute myocardial infarction after docetaxel chemotherapy: case report and literature review

Overcoming immunotherapy resistance in triple-negative breast cancer: a critical review of mast cell plasticity, metabolic reprogramming, and organoid models