Association between metabolic risk factors and hepatocellular carcinoma: a systematic review and meta-analysis of cohort studies - Takeaways - MDSpire

Association between metabolic risk factors and hepatocellular carcinoma: a systematic review and meta-analysis of cohort studies

  • By

  • Xiaoli Yang

  • Peng Fu

  • Hui Liu

  • July 17, 2026

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  • 1

    Hepatocellular carcinoma (HCC) is linked to metabolic disorders, with specific risk factors influencing hepatocarcinogenesis.

  • 2

    The meta-analysis included 73 studies with over 45 million participants, assessing various metabolic risk factors for HCC.

  • 3

    Metabolic syndrome, diabetes mellitus, and elevated waist-to-height ratio are significantly associated with increased HCC risk.

  • 4

    Disturbances in high-density lipoprotein cholesterol levels and elevated low-density lipoprotein cholesterol are linked to decreased HCC risk.

  • 5

    Identifying metabolic risk factors is crucial for understanding HCC development and may inform future screening strategies.

Original Source(s)

Association between metabolic risk factors and hepatocellular carcinoma: a systematic review and meta-analysis of cohort studies

  • by Xiaoli Yang, Peng Fu, Hui Liu

  • July 17, 2026

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