Loss of pituitary hormone function after stereotactic radiosurgery for pituitary adenomas: mechanisms and management

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Pituitary adenomas (PAs) comprise 10% of intracranial tumors and are classified as nonfunctioning or functioning based on hormone secretion.
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Stereotactic radiosurgery (SRS) is used for managing recurrent or residual PAs, aiming to halt tumor growth and normalize hormonal hypersecretion.
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Hypopituitarism is the most common complication of SRS, occurring in 21% to 50% of patients, and can arise from damage to the pituitary gland or surrounding structures.
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Factors influencing endocrine remission after SRS include the absence of hormone-suppressive medications and a higher maximum radiation dose.
5

SRS shows variable endocrine remission rates in acromegaly and Cushing's disease, with predictors including lower IGF-I levels and absence of cavernous sinus invasion.

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