The Gene That Helps Cancer Travel

Study suggests calretinin expression reflects tumor adaptation to bloodstream forces rather than Gleason grade

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CALB2 is identified as a gene linked to the survival of metastatic prostate cancer cells under mechanical stress in the bloodstream.
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The study involved exposing prostate cancer cell lines to high-intensity fluid shear stress, leading to the selection of mechanoresistant cells.
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In aggressive PC3 cells, CALB2 expression was significantly upregulated, contributing to their ability to withstand shear stress.
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Higher calretinin expression was found in prostate adenocarcinoma and metastatic tissue compared to adjacent normal tissue.
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The findings suggest CALB2 may serve as a biomarker for tumor adaptation to mechanical stress, warranting further research.

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