Association of AT1R expression with transplant glomerulopathy and interstitial fibrosis in kidney transplant recipients - Takeaways - MDSpire

Association of AT1R expression with transplant glomerulopathy and interstitial fibrosis in kidney transplant recipients

  • By

  • Katarzyna Jakuszko

  • Piotr Donizy

  • Agnieszka Sas

  • Guido Moll

  • Rusan Catar

  • Renata Trzeciak-Snopczyńska

  • Justyna Zachciał

  • Sławomir Zmonarski

  • Magdalena Kuriata-Kordek

  • Agnieszka Hałoń

  • Maciej Wuczyński

  • Krzysztof Kujawa

  • Dariusz Janczak

  • Mirosław Banasik

  • July 14, 2026

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  • 1

    AT1R expression was found in 44.2% of kidney transplant recipients, correlating with increased transplant glomerulopathy and interstitial fibrosis.

  • 2

    Patients with positive AT1R expression had significantly higher frequencies of transplant glomerulopathy (24% vs. 7%) and interstitial fibrosis (56% vs. 27%).

  • 3

    The severity of interstitial fibrosis was greater in patients with AT1R expression, indicating a potential link to chronic allograft dysfunction.

  • 4

    Anti-AT1R antibody levels did not differ significantly between groups, suggesting they may not be a reliable predictor of graft survival.

  • 5

    The combination of AT1R expression, anti-AT1R antibodies, and histopathological lesions was associated with worse long-term graft survival.

Original Source(s)

Association of AT1R expression with transplant glomerulopathy and interstitial fibrosis in kidney transplant recipients

  • by Katarzyna Jakuszko, Piotr Donizy, Agnieszka Sas, Guido Moll, Rusan Catar, Renata Trzeciak-Snopczyńska, Justyna Zachciał, Sławomir Zmonarski, Magdalena Kuriata-Kordek, Agnieszka Hałoń, Maciej Wuczyński, Krzysztof Kujawa, Dariusz Janczak, Mirosław Banasik

  • July 14, 2026

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